| | |  | | | | Record from Web of Science® | | | | | | |
| Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry |
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| Author(s): McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA |
| Source: NATURE MEDICINE Volume: 11 Issue: 1 Pages: 85-89 Published: JAN 2005 |
| Times Cited: 92 References: 30 |
| Abstract: The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve both genetic and environmental factors. To identify environmental agents that could potentially incite autoimmunity, we have traced the autoantibody response in human SLE back in time, prior to clinical disease onset, and identified the initial autoantigenic epitope for some lupus patients positive for antibodies to 60 kDa Ro. This initial epitope directly cross-reacts with a peptide from the latent viral protein Epstein-Barr virus nuclear antigen-1 (EBNA-1). Animals immunized with either the first epitope of 60 kDa Ro or the cross-reactive EBNA-1 epitope progressively develop autoantibodies binding multiple epitopes of Ro and spliceosomal autoantigens. They eventually acquire clinical symptoms of lupus such as leukopenia, thrombocytopenia and renal dysfunction. These data support the hypothesis that some humoral autoimmunity in human lupus arises through molecular mimicry between EBNA-1 and lupus autoantigens and provide further evidence to suspect an etiologic role for Epstein-Barr virus in SLE. |
| Document Type: Article |
| Language: English |
| Reprint Address: James, JA (reprint author), Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA |
Addresses:
1. Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
2. Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA
3. Dept Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA
4. Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA
5. NIAMSD, Bethesda, MD 20892 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 884ZJ |
| ISSN: 1078-8956 |
| DOI: 10.1038/nm1167 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |