| | |  | | | | Record from Web of Science® | | | | | | |
| A germ cell origin of embryonic stem cells? |
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| Author(s): Zwaka TP, Thomson JA |
| Source: DEVELOPMENT Volume: 132 Issue: 2 Pages: 227-233 Published: JAN 2005 |
| Times Cited: 85 References: 62 |
| Abstract: Because embryonic stem (ES) cells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to be the equivalent of ICM cells. However, various evidence indicates that ICM cells transition to a different cell type during ES-cell derivation. Historically, ES cells have been believed to most closely resemble pluripotent primitive ectoderm cells derived directly from the ICM. However, differences between ES cells and primitive ectoderm cells have caused developmental biologists to question whether ES cells really have an in vivo equivalent, or whether their properties merely reflect their tissue culture environment. Here, we review recent evidence that the closest in vivo equivalent of an ES cell is an early germ cell. |
| Document Type: Review |
| Language: English |
| Reprint Address: Thomson, JA (reprint author), Univ Wisconsin, Sch Med, Madison, WI 53715 USA |
Addresses:
1. Univ Wisconsin, Sch Med, Madison, WI 53715 USA
2. Univ Wisconsin, Natl Primate Res Ctr, Madison, WI 53715 USA
3. WiCell Res Inst, Madison, WI 53715 USA |
| Publisher: COMPANY OF BIOLOGISTS LTD, BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND |
| Subject Category: Developmental Biology |
| IDS Number: 896HQ |
| ISSN: 0950-1991 |
| DOI: 10.1242/dev.01586 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |