| | |  | | | | Record from Web of Science® | | | | | | |
| Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease |
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| Author(s): Hubner N, Wallace CA, Zimdahl H, Petretto E, Schulz H, Maciver F, Mueller M, Hummel O, Monti J, Zidek V, Musilova A, Kren V, Causton H, Game L, Born G, Schmidt S, Muller A, Cook SA, Kurtz TW, Whittaker J, Pravenec M, Aitman TJ |
| Source: NATURE GENETICS Volume: 37 Issue: 3 Pages: 243-253 Published: MAR 2005 |
| Times Cited: 215 References: 50 |
| Abstract: Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this approach to the regulation of gene expression in the BXH/HXB panel of rat recombinant inbred strains, one of the largest available rodent recombinant inbred panels and a leading resource for genetic analysis of the highly prevalent metabolic syndrome. In two tissues important to the pathogenesis of the metabolic syndrome, we mapped cis- and transregulatory control elements for expression of thousands of genes across the genome. Many of the most highly linked expression quantitative trait loci are regulated in cis, are inherited essentially as monogenic traits and are good candidate genes for previously mapped physiological quantitative trait loci in the rat. By comparative mapping we generated a data set of 73 candidate genes for hypertension that merit testing in human populations. Mining of this publicly available data set is expected to lead to new insights into the genes and regulatory pathways underlying the extensive range of metabolic and cardiovascular disease phenotypes that segregate in these recombinant inbred strains. |
| Document Type: Article |
| Language: English |
| Reprint Address: Pravenec, M (reprint author), Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic |
Addresses:
1. Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague 4, Czech Republic
2. Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
3. Univ London Imperial Coll Sci & Technol, Fac Med, Ctr Clin Sci, MRC, London W12 0NN, England
4. Ctr Appl Gen, Prague 14220 4, Czech Republic
5. Charles Univ, Inst Biol & Med Genet, Prague 12000 2, Czech Republic
6. Univ Calif San Francisco, San Francisco, CA 94143 USA
7. Univ London Imperial Coll Sci & Technol, Dept Epidemiol & Publ Hlth, London W2 1PG, England |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 901QU |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng1522 |
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