| | |  | | | | Record from Web of Science® | | | | | | |
| Communicating with Hedgehogs |
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| Author(s): Hooper JE, Scott MP |
| Source: NATURE REVIEWS MOLECULAR CELL BIOLOGY Volume: 6 Issue: 4 Pages: 306-317 Published: APR 2005 |
| Times Cited: 243 References: 120 |
| Abstract: Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution. |
| Document Type: Review |
| Language: English |
| Reprint Address: Hooper, JE (reprint author), Univ Colorado, Sch Med, Dept Cell & Dev Biol, 12801 E 17th Ave,Box 8018, Aurora, CO 80045 USA |
Addresses:
1. Univ Colorado, Sch Med, Dept Cell & Dev Biol, Aurora, CO 80045 USA
2. Stanford Univ, Sch Med, Howard Hughes Med Inst, Clark Ctr W252,Dept Dev Biol, Stanford, CA 94305 USA
3. Stanford Univ, Sch Med, Howard Hughes Med Inst, Clark Ctr W252,Dept Genet & Bioengn, Stanford, CA 94305 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 912EQ |
| ISSN: 1471-0072 |
| DOI: 10.1038/nrm1622 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |