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| IRF-7 is the master regulator of type-I interferon-dependent immune responses |
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| Author(s): Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T |
| Source: NATURE Volume: 434 Issue: 7034 Pages: 772-777 Published: APR 7 2005 |
| Times Cited: 449 References: 30 |
| Abstract: The type-I interferon (IFN-alpha/beta) response is critical to immunity against viruses and can be triggered in many cell types by cytosolic detection of viral infection, or in differentiated plasmacytoid dendritic cells by the Toll-like receptor 9 (TLR9) subfamily, which generates signals via the adaptor MyD88 to elicit robust IFN induction(1-4). Using mice deficient in the Irf7 gene (Irf7(-/-) mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-alpha/beta genes via the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Viral induction of MyD88-independent IFN-alpha/beta genes is severely impaired in Irf7(-/-) fibroblasts. Consistently, Irf7(-/-) mice are more vulnerable than Myd88(-/-) mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity. Furthermore, robust induction of IFN production by activation of the TLR9 subfamily in plasmacytoid dendritic cells is entirely dependent on IRF-7, and this MyD88-IRF-7 pathway governs the induction of CD8(+) T-cell responses. Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7. |
| Document Type: Article |
| Language: English |
| Reprint Address: Taniguchi, T (reprint author), Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan |
Addresses:
1. Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan
2. Univ Tokyo, Fac Med, Tokyo 1130033, Japan
3. Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan
4. JST, PRESTO, Informat & Cell Funct, Kawaguchi, Saitama 3320012 Japan |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 913NU |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature03464 |
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