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Arginine methylation: An emerging regulator of protein function
Author(s): Bedford MT, Richard S
Source: MOLECULAR CELL    Volume: 18    Issue: 3    Pages: 263-272    Published: APR 29 2005  
Times Cited: 241     References: 99     
Abstract: Arginine methylation is now coming out of the shadows of protein phosphorylation and entering the mainstream, largely due to the identification of the family of enzymes that lay down this modification. In addition, modification-specific antibodies and proteomic approaches have facilitated the identification of an array of substrates for the protein arginine methyl-transferases. This review describes recent insights into the molecular processes regulated by arginine methylation in normal and diseased cells.
Document Type: Review
Language: English
Reprint Address: Bedford, MT (reprint author), Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78957 USA
Addresses:
1. Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX 78957 USA
2. McGill Univ, Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Terry Fox Mol Oncol Grp, Montreal, PQ H3T 1E2 Canada
3. McGill Univ, Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Bloomfield Ctr Res Aging, Montreal, PQ H3T 1E2 Canada
4. McGill Univ, Dept Oncol, Montreal, PQ H3T 1E2 Canada
5. McGill Univ, Dept Med, Montreal, PQ H3T 1E2 Canada
Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA
Subject Category: Biochemistry & Molecular Biology; Cell Biology
IDS Number: 922NM
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2005.04.003
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