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| The nervous system and innate immunity: the neuropeptide connection |
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| Author(s): Brogden KA, Guthmiller JM, Salzet M, Zasloff M |
| Source: NATURE IMMUNOLOGY Volume: 6 Issue: 6 Pages: 558-564 Published: JUN 2005 |
| Times Cited: 60 References: 92 |
| Abstract: Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, might directly defend the host from microbial assault. As examples, we have chosen five well described, locally produced neuropeptides that may serve a previously unrecognized, direct antimicrobial, innate immune function in four anatomical sites. |
| Document Type: Review |
| Language: English |
| Reprint Address: Brogden, KA (reprint author), Univ Iowa, Coll Dent, Dept Periodont, Iowa City, IA 52252 USA |
Addresses:
1. Univ Iowa, Coll Dent, Dept Periodont, Iowa City, IA 52252 USA
2. Univ Iowa, Coll Dent, Dow Inst Dent Res, Iowa City, IA 52252 USA
3. Univ & Technol Lille, CNRS, UMR 8017, IFR 118,Lab Neuroimmunol Annelides, F-59650 Villeneuve Dascq, France
4. Georgetown Univ, Med Ctr, Sch Med, Washington, DC 20057 USA |
| Publisher: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, NY 10010-1707 USA |
| Subject Category: Immunology |
| IDS Number: 929ZR |
| ISSN: 1529-2908 |
| DOI: 10.1038/ni1209 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |