| | |  | | | | Record from Web of Science® | | | | | | |
| A microRNA polycistron as a potential human oncogene |
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| Author(s): He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM |
| Source: NATURE Volume: 435 Issue: 7043 Pages: 828-833 Published: JUN 9 2005 |
| Times Cited: 701 References: 28 |
| Abstract: To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, noncoding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas(1). Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir- 17 - 92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir- 17 - 92 cluster as a potential human oncogene. |
| Document Type: Article |
| Language: English |
| Reprint Address: Hannon, GJ (reprint author), Cold Spring Harbor Lab, Watson Sch Biol Sci, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA |
Addresses:
1. Cold Spring Harbor Lab, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
2. Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
3. Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
4. Mem Sloan Kettering Canc Ctr, Div Mol Pathol, New York, NY 10021 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 933NK |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature03552 |
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