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| Temporal control of cell cycle gene expression mediated by E2F transcription factors |
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| Author(s): Zhu WC, Giangrande PH, Nevins JR |
| Source: CELL CYCLE Volume: 4 Issue: 5 Pages: 633-635 Published: MAY 2005 |
| Times Cited: 9 References: 0 |
| Abstract: Various studies now point to the role of cooperative transcription factor interactions as a mechanism to achieve the necessary specificity in promoter recognition. An example can be seen in the action of E2F proteins where interactions with other transcription factors not only provides this general specificity but also the specificity that distinguishes function of the individual E2F proteins. This includes both the activation and repression functions of E2Fs and has now also been extended to the control of G(2)/M regulated genes in addition to the G(1)/S E2F targets. These studies further highlight events linking the control of G(1)/S genes with G(2)/M, providing a mechanism to achieve the temporal control of gene expression as cells move through the cell cycle. |
| Document Type: Article |
| Language: English |
| Reprint Address: Nevins, JR (reprint author), Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA |
Addresses:
1. Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA |
| Publisher: LANDES BIOSCIENCE, 810 SOUTH CHURCH STREET, GEORGETOWN, TX 78626 USA |
| Subject Category: Cell Biology |
| IDS Number: 933UH |
| ISSN: 1538-4101 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |