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| Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network |
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| Author(s): Rosen H, Goetzl EJ |
| Source: NATURE REVIEWS IMMUNOLOGY Volume: 5 Issue: 7 Pages: 560-570 Published: JUL 2005 |
| Times Cited: 229 References: 76 |
| Abstract: Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of G-protein-coupled receptors to control cellular differentiation and survival, as well as the vital functions of several types of immune cell. In this Review article, we discuss recent results that indicate that S1P and its receptors are required for the emigration of thymocytes from the thymus, the trafficking of lymphocytes in secondary lymphoid organs and the migration of B cells into splenic follicles. In an autocrine manner, through interactions with different G-protein-coupled receptors, S1P also enhances optimal mast-cell migration and release of pro-inflammatory mediators in allergic reactions. S1P - S1P- receptor regulatory systems might therefore be novel targets for the therapy of diverse immunological diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: Goetzl, EJ (reprint author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA |
Addresses:
1. Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
2. Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
3. Univ Calif San Francisco, Dept Microbiol Immunol, San Francisco, CA 94143 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 944KL |
| ISSN: 1474-1733 |
| DOI: 10.1038/nri1650 |
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