| | |  | | | | Record from Web of Science® | | | | | | |
| Using Drosophila melanogaster to map human cancer pathways |
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| Author(s): Brumby AM, Richardson HE |
| Source: NATURE REVIEWS CANCER Volume: 5 Issue: 8 Pages: 626-639 Published: AUG 2005 |
| Times Cited: 50 References: 152 |
| Abstract: The development of human cancer is a multistep process, involving the cooperation of mutations in signalling, cell-cycle and cell-death pathways, as well as interactions between the tumour and the tumour microenvironment. To dissect the steps of tumorigenesis, simple animal models are needed. This article discusses the use of the genetically amenable, multicellular organism, the vinegar fly Drosophila melanogaster. In particular, recent studies have highlighted the power of D. melanogaster for examining cooperative interactions between tumour suppressors and oncogenes and for generating in vivo models of tumour development and metastasis. |
| Document Type: Review |
| Language: English |
| Reprint Address: Brumby, AM (reprint author), Peter MacCallum Canc Ctr, Cell Cycle & Dev Grp, Div Res, 7 St Andrews Pl, Melbourne, Vic 3002 Australia |
Addresses:
1. Peter MacCallum Canc Ctr, Cell Cycle & Dev Grp, Div Res, Melbourne, Vic 3002 Australia |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 950TR |
| ISSN: 1474-175X |
| DOI: 10.1038/nrc1671 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |