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| A simplified laminin nomenclature |
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| Author(s): Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JCR, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD |
| Source: MATRIX BIOLOGY Volume: 24 Issue: 5 Pages: 326-332 Published: AUG 2005 |
| Times Cited: 188 References: 10 |
| Abstract: A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha 5 beta 1 gamma 1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of 13 chains is named laminin beta-knob (L beta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha IL4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered. (C) 2005 Elsevier B.V./Intemational Society of Matrix Biology. All rights reserved. |
| Document Type: Review |
| Language: English |
| Reprint Address: Ekblom, P (reprint author), Lund Univ, Dept Expt Med Sci, Lund, Sweden |
Addresses:
1. Lund Univ, Dept Expt Med Sci, Lund, Sweden
2. Univ Cologne, Fac Med, Ctr Biochem, Cologne, Germany
3. Univ Freiburg, Dept Dermatol, D-7800 Freiburg, Germany
4. Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
5. Univ Regensburg, Dept Biochem Microbiol & Genet, D-8400 Regensburg, Germany
6. Univ Liverpool, Dept Anat, Liverpool L69 3BX, Merseyside England
7. Univ Basel, Biozentrum, Basel, Switzerland
8. Burnham Inst, La Jolla, CA 92037 USA
9. Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London, England
10. Northwestern Univ, Dept Cell & Mol Biol, Chicago, IL 60611 USA
11. Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA
12. Stanford Univ, Sch Med, VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA
13. Stanford Univ, Sch Med, Program Epithelial Biol, Palo Alto, CA 94304 USA
14. Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Manchester, Lancs England
15. Univ Nice, Sch Med, INSERM, U634, Nice, France
16. Washington Univ, Sch Med, Div Renal, St Louis, MO 63110 USA
17. Yokohama City Univ, Kihara Inst Biol Res, Yokohama, Kanagawa 232 Japan
18. Karolinska Inst, Dept Odontol, Stockholm, Sweden
19. Vanderbilt Univ, Dept Canc Biol, Nashville, TN USA
20. Harvard Univ, Ctr Brain Sci, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
21. Max Planck Inst Biochem, D-8033 Martinsried, Germany
22. Osaka Univ, Inst Prot Res, Osaka, Japan
23. Lund Univ, Dept Expt Pathol, Lund, Sweden
24. Royal Vet & Agr Univ, Dept Anim & Vet Basic Sci, Frederiksberg, Denmark
25. Karolinska Inst, Dept Biochem & Biophys, Stockholm, Sweden
26. Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA
27. Univ Helsinki, Dept Anat, FIN-00014 Helsinki, Finland
28. Univ Erlangen Nurnberg, Dept Expt Med 1, Erlangen, Germany
29. Univ Copenhagen, Inst Mol Pathol, Copenhagen, Denmark
30. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pathol, Piscataway, NJ 08854 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 955DL |
| ISSN: 0945-053X |
| DOI: 10.1016/j.matbio.2005.05.006 |
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