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Reversing histone methylation
Author(s): Bannister AJ, Kouzarides T
Source: NATURE    Volume: 436    Issue: 7054    Pages: 1103-1106    Published: AUG 25 2005  
Times Cited: 141     References: 36     
Abstract: Histones package DNA, and post-translational modifications of histones can regulate access to DNA. Until recently, histone methylation - unlike all other histone modifications - was considered a permanent mark. The discovery of enzymes that reverse the methylation of lysines and arginines challenges our current thinking on the unique nature of histone methylation, and substantially increases the complexity of histone modification pathways.
Document Type: Article
Language: English
Reprint Address: Kouzarides, T (reprint author), Gurdon Inst, Tennis Court Rd, Cambridge CB2 1QN, England
Addresses:
1. Gurdon Inst, Cambridge CB2 1QN, England
2. Dept Pathol, Cambridge CB2 1QN, England
Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Subject Category: Multidisciplinary Sciences
IDS Number: 958AK
ISSN: 0028-0836
DOI: 10.1038/nature04048
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