| | |  | | | | Record from Web of Science® | | | | | | |
| Molecular lymphangiogenesis: new players |
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| Author(s): Tammela T, Petrova TV, Alitalo K |
| Source: TRENDS IN CELL BIOLOGY Volume: 15 Issue: 8 Pages: 434-441 Published: AUG 2005 |
| Times Cited: 41 References: 89 |
| Abstract: The function of the lymphatic vascular system as a conduit for immune cells and excess tissue fluid has been known for over a century, but the molecular players involved in lymphangiogenesis - the formation of lymphatic vessels - have remained unknown until recently. Signals mediated by vascular endothelial growth factor-C, the homeodomain transcription factor PROX1 and the forkhead transcription factor FOXC2 have been implicated in the growth, morphogenesis and hierarchic organization of the lymphatic vascular network. Recent results have also shown the importance of the angiopoietin-Tie and ephrin-Eph signaling systems in lymphangiogenesis, suggesting that these pathways regulate the lymphatic vascular system in a manner similar to, yet distinct from, their regulation of angiogenesis. This review provides an overview of the molecular players involved in lymphangiogenesis, with special emphasis on recently discovered molecular mechanisms. |
| Document Type: Review |
| Language: English |
| Reprint Address: Alitalo, K (reprint author), Univ Helsinki, Mol Canc Biol Lab, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland |
Addresses:
1. Univ Helsinki, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland
2. Univ Helsinki, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland
3. Univ Helsinki, Dev & Differentiat Lab, Mol Canc Biol Program, Biomedicum Helsinki, FIN-00014 Helsinki, Finland
4. Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Cell Biology |
| IDS Number: 959MJ |
| ISSN: 0962-8924 |
| DOI: 10.1016/j.tcb.2005.06.004 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |