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| The metabolic syndrome: Time for a critical appraisal - Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes |
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| Author(s): Kahn R, Buse J, Ferrannini E, Stern M |
| Source: DIABETES CARE Volume: 28 Issue: 9 Pages: 2289-2304 Published: SEP 2005 |
| Times Cited: 678 References: 171 |
| Abstract: The term "metabolic syndrome" refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance. Since the term is widely used in research and clinical practice, we undertook an extensive review of the literature in relation to the syndrome's definition, underlying pathogenesis, and association with CVD and to the goals and impact of treatment. While there is no question that certain CVD risk factors are prone to cluster, we found that the metabolic syndrome has been imprecisely defined, there is a lack of certainty regarding its pathogenesis, and there is considerable doubt regarding its value as a CVD risk marker. Our analysis indicates that too much critically important information is missing to warrant its designation as a "syndrome." Until much needed research is completed, clinicians should evaluate and treat all CVD risk factors without regard to whether a patient meets the criteria for diagnosis of the "metabolic syndrome." |
| Document Type: Review |
| Language: English |
| Reprint Address: Kahn, R (reprint author), Amer Diabet Assoc, 1701 N Beauregard St, Alexandria, VA 22311 USA |
Addresses:
1. Amer Diabet Assoc, Alexandria, VA 22311 USA
2. Univ N Carolina, Sch Med, Div Endocrinol & Gen Med & Clin Epidemiol, Chapel Hill, NC USA
3. Univ Pisa, Sch Med, Dept Internal Med, I-56100 Pisa, Italy
4. Univ Texas, Hlth Sci Ctr, Dept Med, Div Clin Epidemiol, San Antonio, TX 78284 USA |
| Publisher: AMER DIABETES ASSOC, 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA |
| Subject Category: Endocrinology & Metabolism |
| IDS Number: 959NV |
| ISSN: 0149-5992 |
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