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| Arsenic trioxide in the treatment of acute promyelocytic leukemia. A review of current evidence |
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| Author(s): Sanz MA, Fenaux P, Lo Coco F |
| Source: HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Volume: 90 Issue: 9 Pages: 1231-1235 Published: SEP 2005 |
| Times Cited: 34 References: 37 |
| Abstract: Recent studies have demonstrated the beneficial effects of arsenic trioxide (ATO) in the treatment of relapsed acute promyelocytic leukemia (APL). The aim of this review is to discuss the role of ATO in the management of APL. Based on the available clinical evidence, a tentative algorithm is proposed for the treatment of patients who relapse after or are refractory to all trans-retinoic acid-based therapy. Other opportunities for the use of ATO in front-line treatment of APL are also discussed, especially its potential use in patients at high risk of relapse and in those with contraindications to chemotherapy or in whom the amount of chemotherapy should be reduced. |
| Document Type: Review |
| Language: English |
| Reprint Address: Sanz, MA (reprint author), Univ Valencia, Hosp La Fe, Hematol Serv, Ave Campanar 21, Valencia 46009, Spain |
Addresses:
1. Univ Valencia, Hosp La Fe, Hematol Serv, Valencia 46009, Spain
2. Univ Roma Tor Vergata, Rome, Italy
3. Univ Klinikum Munster, Munster, Germany
4. Univ Wales Coll Cardiff, Coll Med, Cardiff, Wales
5. Univ Roma La Sapienza, Rome, Italy
6. Univ Ulm Klinikum, D-7900 Ulm, Germany
7. Univ Paris, Hop St Louis, Inst Hematol, F-75252 Paris, France
8. Univ Klinikum Mannheim, Mannheim, Germany
9. Univ Roma Tor Vergata, Rome, Italy
10. Erasmus Univ Hosp Rotterdam Dijkzigt, Rotterdam, Netherlands
11. Wilhelminenspital Stadt Wien, Vienna, Austria
12. Univ Paris 13, Paris, France |
| Publisher: FERRATA STORTI FOUNDATION, STRADA NUOVA 134, 27100 PAVIA, ITALY |
| Subject Category: Hematology |
| IDS Number: 967DR |
| ISSN: 0390-6078 |
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