| | |  | | | | Record from Web of Science® | | | | | | |
| Regulation of mammalian tooth cusp patterning by ectodin |
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| Author(s): Kassai Y, Munne P, Hotta YH, Penttila E, Kavanagh K, Ohbayashi N, Takada S, Thesleff I, Jernvall J, Itoh N |
| Source: SCIENCE Volume: 309 Issue: 5743 Pages: 2067-2070 Published: SEP 23 2005 |
| Times Cited: 68 References: 26 |
| Abstract: Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial, signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative'! image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps. |
| Document Type: Article |
| Language: English |
| Reprint Address: Jernvall, J (reprint author), Univ Helsinki, Viikki Bioctr, Inst Biotechnol, Dev Biol Program, POB 56, FIN-00014 Helsinki, Finland |
Addresses:
1. Univ Helsinki, Viikki Bioctr, Inst Biotechnol, Dev Biol Program, FIN-00014 Helsinki, Finland
2. Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Biochem Genet, Kyoto 6068501, Japan
3. Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787 Japan
4. SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 968SF |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1116848 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |