| | |  | | | | Record from Web of Science® | | | | | | |
| Trim family proteins: Retroviral restriction and antiviral defence |
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| Author(s): Nisole S, Stoye JP, Saib A |
| Source: NATURE REVIEWS MICROBIOLOGY Volume: 3 Issue: 10 Pages: 799-808 Published: OCT 2005 |
| Times Cited: 136 References: 128 |
| Abstract: Members of the tripartite motif ( TRIM) protein family are involved in various cellular processes, including cell proliferation, differentiation, development, oncogenesis and apoptosis. Some TRIM proteins display antiviral properties, targeting retroviruses in particular. The potential activity of TRIM19, better known as promyelocytic leukaemia protein, against several viruses has been well documented and, recently, TRIM5 alpha has been identified as the factor responsible for the previously described Lv1 and Ref1 antiretroviral activities. There is also evidence indicating that other TRIM proteins can influence viral replication. These findings are reviewed here, and the possibility that TRIMs represent a new and widespread class of antiviral proteins involved in innate immunity is also considered. |
| Document Type: Review |
| Language: English |
| Reprint Address: Nisole, S (reprint author), Univ Paris 07, UMR 7151, CNRS, Hop St Louis, 1 Ave Claude Vellefaux, F-75475 Paris, France |
Addresses:
1. Univ Paris 07, UMR 7151, CNRS, Hop St Louis, F-75475 Paris, France
2. Natl Inst Med Res, Div Virol, London NW7 1AA, England |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Microbiology |
| IDS Number: 972ZP |
| ISSN: 1740-1526 |
| DOI: 10.1038/nrmicro1248 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |