| | |  | | | | Record from Web of Science® | | | | | | |
| Interlinked fast and slow positive feedback loops drive reliable cell decisions |
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| Author(s): Brandman O, Ferrett JE, Li R, Meyer T |
| Source: SCIENCE Volume: 310 Issue: 5747 Pages: 496-498 Published: OCT 21 2005 |
| Times Cited: 117 References: 29 |
| Abstract: Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and stow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system. |
| Document Type: Article |
| Language: English |
| Reprint Address: Brandman, O (reprint author), Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA
2. Marine Biol Lab, Physiol Course 2004, Woods Hole, MA 02543 USA
3. Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
4. Stowers Inst Med Res, Kansas City, MO 64110 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 977EU |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1113834 |
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