| | |  | | | | Record from Web of Science® | | | | | | |
| "Phosphatonins" and the regulation of phosphorus homeostasis |
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| Author(s): Berndt TJ, Schiavi S, Kumar R |
| Source: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Volume: 289 Issue: 6 Pages: F1170-F1182 Published: DEC 2005 |
| Times Cited: 45 References: 139 |
| Abstract: Phosphate ions are critical for normal bone mineralization, and phosphate plays a vital role in a number of other biological processes such as signal transduction, nucleotide metabolism, and enzyme regulation. The study of rare disorders associated with renal phosphate wasting has resulted in the discovery of a number of proteins [ fibroblast growth factor 23 (FGF-23), secreted frizzled related protein 4 (sFRP-4), matrix extracellular phosphoglycoprotein, and FGF 7 (FGF-7)] that decrease renal sodium-dependent phosphate transport in vivo and in vitro. The "phosphatonins," FGF-23 and sFRP-4, also inhibit the synthesis of 1 alpha,25-dihydroxyvitamin D, leading to decreased intestinal phosphate absorption and further reduction in phosphate retention by the organism. In this review, we discuss the biological properties of these proteins, alterations in their concentrations in various clinical disorders, and their possible physiological role. |
| Document Type: Review |
| Language: English |
| Reprint Address: Kumar, R (reprint author), Mayo Coll Med, Mayo Clin, Dept Med, Div Nephrol & Hypertens, 200 1st St,SW, Rochester, MN 55905 USA |
Addresses:
1. Mayo Coll Med, Mayo Clin, Dept Med, Div Nephrol & Hypertens, Rochester, MN 55905 USA
2. Mayo Coll Med, Mayo Clin, Dept Biochem & Mol Biol, Div Nephrol & Hypertens, Rochester, MN 55905 USA
3. Genzyme Corp, Receptor Ligand Therapeut, Framingham, MA USA |
| Publisher: AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Physiology; Urology & Nephrology |
| IDS Number: 981RA |
| ISSN: 0363-6127 |
| DOI: 10.1152/ajprenal.00072.2005 |
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