| | |  | | | | Record from Web of Science® | | | | | | |
| Hypoxia requires Notch signaling to maintain the undifferentiated cell state |
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| Author(s): Gustafsson MV, Zheng XW, Pereira T, Gradin K, Jin SB, Lundkvist J, Ruas JL, Poellinger L, Lendahl U, Bondesson M |
| Source: DEVELOPMENTAL CELL Volume: 9 Issue: 5 Pages: 617-628 Published: NOV 2005 |
| Times Cited: 176 References: 51 |
| Abstract: In addition to controlling a switch to glycolytic metabolism and induction of erythropoiesis and angiogenesis, hypoxia promotes the undifferentiated cell state in various stem and precursor cell populations. Here, we show that the latter process requires Notch signaling. Hypoxia blocks neuronal and myogenic differentiation in a Notch-dependent manner. Hypoxia activates Notch-responsive promoters and increases expression of Notch direct downstream genes. The Notch intracellular domain interacts with HIF-1 alpha, a global regulator of oxygen homeostasis, and HIF-1a is recruited to Notch-responsive promoters upon Notch activation under hypoxic conditions. Taken together, these data provide molecular insights into how reduced oxygen levels control the cellular differentiation status and demonstrate a role for Notch in this process. |
| Document Type: Article |
| Language: English |
| Reprint Address: Lendahl, U (reprint author), Karolinska Inst, Med Noble Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden |
Addresses:
1. Karolinska Inst, Med Noble Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Cell Biology; Developmental Biology |
| IDS Number: 982UI |
| ISSN: 1534-5807 |
| DOI: 10.1016/j.devcel.2005.09.010 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |