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| Reconstruction of genetic circuits |
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| Author(s): Sprinzak D, Elowitz MB |
| Source: NATURE Volume: 438 Issue: 7067 Pages: 443-448 Published: NOV 24 2005 |
| Times Cited: 109 References: 48 |
| Abstract: The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach: one can construct and analyse synthetic genetic circuits based on their natural counterparts. Such synthetic circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit. Here we describe recent progress in this area of synthetic biology, highlighting newly developed genetic components and biological lessons learned from this approach. |
| Document Type: Review |
| Language: English |
| Reprint Address: Elowitz, MB (reprint author), CALTECH, Div Biol, Pasadena, CA 91125 USA |
Addresses:
1. CALTECH, Div Biol, Pasadena, CA 91125 USA
2. CALTECH, Dept Appl Phys, Pasadena, CA 91125 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 986NY |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature04335 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |