| | |  | | | | Record from Web of Science® | | | | | | |
| Plasma membrane phosphoinositide organization by protein electrostatics |
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| Author(s): McLaughlin S, Murray D |
| Source: NATURE Volume: 438 Issue: 7068 Pages: 605-611 Published: DEC 1 2005 |
| Times Cited: 204 References: 85 |
| Abstract: Phosphatidylinositol 4,5- bisphosphate ( PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through several structured domains and has other roles. How can a single lipid in a fluid bilayer regulate so many distinct physiological processes? Spatial organization might be the key to this. Recent studies suggest that membrane proteins concentrate PIP2 and, in response to local increases in intracellular calcium concentration, release it to interact with other biologically important molecules. |
| Document Type: Review |
| Language: English |
| Reprint Address: McLaughlin, S (reprint author), SUNY Stony Brook, Hlth Sci Ctr, Dept Physiol & Biophys, Stony Brook, NY 11794 USA |
Addresses:
1. SUNY Stony Brook, Hlth Sci Ctr, Dept Physiol & Biophys, Stony Brook, NY 11794 USA
2. Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 988JY |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature04398 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |