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| The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion |
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| Author(s): MacDonald KPA, Rowe V, Bofinger HM, Thomas R, Sasmono T, Hume DA, Hill GR |
| Source: JOURNAL OF IMMUNOLOGY Volume: 175 Issue: 3 Pages: 1399-1405 Published: AUG 1 2005 |
| Times Cited: 39 References: 33 |
| Abstract: The lineage of dendritic cells (DC), and in particular their relationship to monocytes and macrophages, remains obscure. Furthermore, the requirement for the macrophage growth factor CSF-1 during DC homeostasis is unclear. Using a transgenic mouse in which the promoter for the CSF-1R (c-fms) directs the expression of enhanced GFP in cells of the myeloid lineage, we determined that although the c-fms promoter is inactive in DC precursors, it is up-regulated in all DC subsets during differentiation. Furthermore, plasmacytoid DC and all CD11c(high) DC subsets are reduced by 50-70% in CSF-1-deficient osteopetrotic mice, confirming that CSF-1 signaling is required for the optimal differentiation of DC in vivo. These data provide additional evidence that the majority of tissue DC is of myeloid origin during steady state and supports a close relationship between DC and macrophage biology in vivo. |
| Document Type: Article |
| Language: English |
| Reprint Address: MacDonald, KPA (reprint author), Queensland Inst Med Res, Bone Marrow Transplantat Lab, 300 Herston Rd, Herston, Qld 4006 Australia |
Addresses:
1. Queensland Inst Med Res, Bone Marrow Transplantat Lab, Herston, Qld 4006 Australia
2. Univ Queensland, Princess Alexandra Hosp, Ctr Immunol & Canc Res, Woolloongabba, Qld Australia
3. Univ Queensland, Cooperat Res Ctr Chron Inflammatory Dis, Inst Mol Biosci, Woolloongabba, Qld Australia
4. Univ Queensland, Australian Res Council, Special Res Ctr Funct Appl Genom, Inst Mol Biosci, Woolloongabba, Qld Australia |
| Publisher: AMER ASSOC IMMUNOLOGISTS, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA |
| Subject Category: Immunology |
| IDS Number: 989BN |
| ISSN: 0022-1767 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |