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| Oxidative stress by peripheral blood mononuclear cells is increased in hypertensives with an extreme-dipper pattern and/or morning surge in blood pressure |
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| Author(s): Maeda K, Yasunari K, Watanabe T, Nakamura M |
| Source: HYPERTENSION RESEARCH Volume: 28 Issue: 9 Pages: 755-761 Published: SEP 2005 |
| Times Cited: 15 References: 26 |
| Abstract: Because oxidative stress and inflammation are known to play important roles in the pathogenesis of cardiovascular events that occur most frequently in the morning, we studied the association between reactive oxygen species (ROS) formation by polymorphonuclear leukocytes (PMNs) or mononuclear cells (MNCs) and morning blood pressure (BP) rhythm. A total of 31 hypertensives in whom ambulatory BP monitoring was performed participated in this study. They were first divided into three groups according to their nocturnal BP rhythm (non-dippers, dippers and extreme dippers), and then into two groups according to their morning BID change (surge-type and sustained-type). ROS formation by PMNs and MNCs was measured by gated flow cytometry. C-reactive protein and traditional risk factors such as age, gender, body mass index, hemoglobin A(1c), and total cholesterol were also measured. ROS formation by MNCs was significantly increased in extreme dippers (vs. dippers, p<0.05, n=11) and in morning BID surge-type hypertensives (vs. sustained-type, p<0.05, n=13). In patients who were both extreme dippers and morning BID surge-types, ROS formation by MNCs was significantly higher than that in other groups. These results suggest that both extreme dippers and morning BP surge-type hypertensives may suffer increased ROS formation by MNCs, and that increased ROS formation by MNCs may underlie morning strokes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Yasunari, K (reprint author), Osaka City Univ, Grad Sch Med, Dept Med & Cardiol, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan |
Addresses:
1. Osaka City Univ, Grad Sch Med, Dept Med & Cardiol, Abeno Ku, Osaka 5458585, Japan |
| Publisher: JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE, SENRI ASAHI HANKYU BLDG, 13TH FLOOR, 1-5-3 SHINSENRIHIGASHI-MACHI, TOYONAKA, 560-0082, JAPAN |
| Subject Category: Peripheral Vascular Disease |
| IDS Number: 995BY |
| ISSN: 0916-9636 |
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