| | |  | | | | Record from Web of Science® | | | | | | |
| Treating erectile dysfunction by endothelial rehabilitation with phosphodiesterase 5 inhibitors |
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| Author(s): Sommer F, Schulze W |
| Source: WORLD JOURNAL OF UROLOGY Volume: 23 Issue: 6 Pages: 385-392 Published: DEC 2005 |
| Times Cited: 25 References: 31 |
| Abstract: A large body of evidence has accumulated demonstrating that a common pathway in conditions such as hypertension, atherosclerosis, hypercholesterolemia, diabetes mellitus, and erectile dysfunction (ED) is endothelial dysfunction. Although a complete pharmacological cure for ED is currently unavailable, the phosphodiesterase 5 (PDE5) inhibitors sildenafil, vardenafil, and tadalafil are efficacious oral therapy for ED. Results from recent studies suggest that regular treatment with a PDE5 inhibitor may lead to enhanced erectile function (EF) beyond that observed with on-demand usage, possibly through improvement of endothelial function. Such an effect may be viewed as rehabilitation of damaged erectile tissue. The present review focuses on several recent studies which provide evidence for the beneficial effect of regular PDE5 inhibitor administration on the improvement of EF by rehabilitation of vascular endothelium. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sommer, F (reprint author), Univ Hamburg, Hosp Eppendorf, Dept Mens Hlth, POB 202101, D-20214 Hamburg, Germany |
Addresses:
1. Univ Hamburg, Hosp Eppendorf, Dept Mens Hlth, D-20214 Hamburg, Germany
2. Univ Hamburg, Hosp Eppendorf, Urol Clin, D-20214 Hamburg, Germany
3. Univ Hamburg, Hosp Eppendorf, Dept Androl, D-20214 Hamburg, Germany |
| Publisher: SPRINGER, 233 SPRING STREET, NEW YORK, NY 10013 USA |
| Subject Category: Urology & Nephrology |
| IDS Number: 995QB |
| ISSN: 0724-4983 |
| DOI: 10.1007/s00345-005-0021-7 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |