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| Epidermal Langerhans cell-deficient mice develop enhanced contact hypersensitivity |
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| Author(s): Kaplan DH, Jenison MC, Saeland S, Shlomchik WD, Shlomchik MJ |
| Source: IMMUNITY Volume: 23 Issue: 6 Pages: 611-620 Published: DEC 2005 |
| Times Cited: 124 References: 45 |
| Abstract: Epidermal Langerhans cells (LCs), a distinct skin-resident dendritic cell population, acquire antigen in the skin and migrate to draining lymph nodes where they are thought to initiate adaptive immune responses. To examine the functional requirement of LCs in skin immunity, we generated BAC transgenic mice in which the regulatory elements from human Langerin were used to drive expression of diphtheria toxin. The resulting mice have a constitutive and durable absence of epidermal LCs but are otherwise intact. Unexpectedly, we found that contact hypersensitivity (CHS) was amplified rather than abrogated in the absence of LCs. Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function. |
| Document Type: Article |
| Language: English |
| Reprint Address: Kaplan, DH (reprint author), Yale Univ, Sch Med, Dept Dermatol, 333 Cedar St, New Haven, CT 06520 USA |
Addresses:
1. Yale Univ, Sch Med, Dept Dermatol, New Haven, CT 06520 USA
2. INSERM, U503, IFR 128, F-69369 Lyon 7, France
3. Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06520 USA
4. Yale Univ, Sch Med, Immunol Sect, New Haven, CT 06520 USA
5. Yale Univ, Sch Med, Med Oncol Sect, New Haven, CT 06520 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Immunology |
| IDS Number: 998KH |
| ISSN: 1074-7613 |
| DOI: 10.1016/j.immuni.2005.10.008 |
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