| | |  | | | | Record from Web of Science® | | | | | | |
| A critical role for myosin IIB in dendritic spine morphology and synaptic function |
|
|
| Author(s): Ryu JB, Liu LD, Wong TP, Wu DC, Burette A, Weinberg R, Wang YT, Sheng M |
| Source: NEURON Volume: 49 Issue: 2 Pages: 175-182 Published: JAN 19 2006 |
| Times Cited: 28 References: 48 |
| Abstract: Dendritic spines show rapid motility and plastic morphology, which may mediate information storage in the brain. It is presently believed that polymerization/ depolymerization of actin is the primary determinant of spine motility and morphogenesis. Here, we show that myosin IIB, a molecular motor that binds and contracts actin filaments, is essential for normal spine morphology and dynamics and represents a distinct biophysical pathway to control spine size and shape. Myosin IIB is enriched in the postsynaptic density (PSD) of neurons. Pharmacologic or genetic inhibition of myosin IIB alters protrusive motility of spines, destabilizes their classical mushroom-head morphology, and impairs excitatory synaptic transmission. Thus, the structure and function of spines is regulated by an actin-based motor in addition to the polymerization state of actin. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sheng, M (reprint author), MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, RIKEN,Nueorsci Res Ctr, Cambridge, MA 02139 USA |
Addresses:
1. MIT, Howard Hughes Med Inst, Picower Inst Learning & Memory, RIKEN,Nueorsci Res Ctr, Cambridge, MA 02139 USA
2. Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5 Canada
3. Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 007OV |
| ISSN: 0896-6273 |
| DOI: 10.1016/j.neuron.2005.12.017 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |