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| Effect of p75(NTR) on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye |
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| Author(s): Harada C, Harada T, Nakamura K, Sakai Y, Tanaka K, Parada LF |
| Source: DEVELOPMENTAL BIOLOGY Volume: 290 Issue: 1 Pages: 57-65 Published: FEB 1 2006 |
| Times Cited: 11 References: 57 |
| Abstract: Neurotrophins induce neural cell survival and differentiation during retinal development and regeneration through the high-affinity tyrosine kinase (Trk) receptors. On the other hand, nerve growth factor (NGF) binding to the low-affinity neurotrophin receptor p75 (p75(NTR)) might induce programmed cell death (PCD) in the early phase of retinal development. In the present study, we examined the retinal cell types that experience p75(NTR)-induced PCD and identify them to be postmitotic retinal ganglion cells (RGCs). However, retinal morphology, RGC number, and BrdU-positive cell number in p75(NTR) knockout (KO) mouse were normal after embryonic day 15 (E15). In chick retina, migratory RGCs express p75(NTR), whereas layered RGCs express the high-affinity NGF receptor TrkA, which may switch the pro-apoptotic signaling of p75(NTR) into a neurotrophic one. In contrast to the chick model, migratory RGCs express TrkA, while stratified RGCs express p75(NTR) in mouse retina. However, RGC number in TrkA KO mouse was also normal at birth. We next examined the expression of transforming growth factor beta (TGF beta) receptor, which modulates chick RGC number in combination with p75(NTR), but was absent in mouse RGCs. p75(NTR) and TrkA seem to be involved in the regulation of mouse RGC number in the early phase of retinal development, but the number may be later adjusted by other molecules. These results suggest the different mechanism of RGC number control between mouse and chick retina. (c) 2005 Elsevier Inc. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Harada, T (reprint author), Tokyo Metropolitan Inst Neurosci, Dept Mol Neurobiol, 2-6 Musashidai, Fuchu, Tokyo 1838526 Japan |
Addresses:
1. Tokyo Metropolitan Inst Neurosci, Dept Mol Neurobiol, Fuchu, Tokyo 1838526 Japan
2. Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA
3. Univ Texas, SW Med Ctr, Kent Waldrep Fdn, Ctr Basic Res Nerve Growth & Regenerat, Dallas, TX 75390 USA
4. Tokyo Med & Dent Univ, Sch Biomed Sci, Lab Mol Neurosci, Tokyo 1138510, Japan
5. Tokyo Med & Dent Univ, Med Res Inst, Tokyo 1138510, Japan
6. JST, Japan Sci & Technol Corp, PRESTO, Kawaguchi, Saitama 3320012 Japan |
| Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA |
| Subject Category: Developmental Biology |
| IDS Number: 008KR |
| ISSN: 0012-1606 |
| DOI: 10.1016/j.ydbio.2005.08.051 |
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