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| Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells |
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| Author(s): Horckmans M, Marcet B, Marteau F, Bulte F, Maho A, Parmentier M, Boeynaems JM, Communi D |
| Source: FEBS LETTERS Volume: 580 Issue: 3 Pages: 747-754 Published: FEB 6 2006 |
| Times Cited: 8 References: 22 |
| Abstract: Extracellular ATP is known to affect the maturation of monocyte-derived dendritic cells mainly by regulation of cytokines and costimulatory molecules. The present study describes the inhibition of MCP-1 (CCL2) and MIP-1 alpha (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Our pharmacological data support the involvement of P2Y(11) and P2Y(1) purinergic receptors in the downregulation of these major monocyte recruiters. Migration assays have demonstrated that supernatants of dendritic cells treated with adenine nucleotides or anti-MCP-1/MIP-1 alpha blocking antibodies display a strongly reduced capacity to attract monocytes and immature dendritic cells. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| Document Type: Article |
| Language: English |
| Reprint Address: Communi, D (reprint author), Free Univ Brussels, Fac Med, IRIBHM, Inst Interdisciplinary Res, 808 Route Lennik,Campus Erasme,Bldg C 5th Floor, B-1070 Brussels, Belgium |
Addresses:
1. Free Univ Brussels, Fac Med, IRIBHM, Inst Interdisciplinary Res, B-1070 Brussels, Belgium
2. Univ Libre Bruxelles, Erasme Hosp, Dept Med Chem, Brussels, Belgium |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| IDS Number: 010UD |
| ISSN: 0014-5793 |
| DOI: 10.1016/j.febslet.2005.12.091 |
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