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| Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C-elegans development |
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| Author(s): Suzuki Y, Han M |
| Source: GENES & DEVELOPMENT Volume: 20 Issue: 4 Pages: 423-428 Published: FEB 15 2006 |
| Times Cited: 7 References: 32 |
| Abstract: Genetic redundancy is associated with a large percentage of genes. We investigated PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene functions that eluded single mutant analyses, using a Caenorhabditis elegans genome-wide screen. We show that at least 27 genes collaborate with the worm PTEN homolog daf-18 for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg laying, and oocyte maturation. In one example, daf-18 appears to constitute a cell-autonomous germline signal that converges with a somatic gonad signal mediated by ceh-18 at a kinase inhibition. We provide evidence that daf-18 elicits some functions independent of the downstream gene daf-16. |
| Document Type: Article |
| Language: English |
| Reprint Address: Han, M (reprint author), Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA |
Addresses:
1. Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA
2. Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA |
| Publisher: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2924 USA |
| Subject Category: Cell Biology; Developmental Biology; Genetics & Heredity |
| IDS Number: 013SB |
| ISSN: 0890-9369 |
| DOI: 10.1101/gad.1378906 |
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