| | |  | | | | Record from Web of Science® | | | | | | |
| Control of translation and mRNA degradation by miRNAs and siRNAs |
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| Author(s): Valencia-Sanchez MA, Liu JD, Hannon GJ, Parker R |
| Source: GENES & DEVELOPMENT Volume: 20 Issue: 5 Pages: 515-524 Published: MAR 1 2006 |
| Times Cited: 365 References: 93 |
| Abstract: The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells. These small RNAs that control gene expression can be either endogenous or exogenous micro RNAs (miRNAs) and short interfering RNAs (siRNAs) and can affect mRNA degradation and translation, as well as chromatin structure, thereby having impacts on transcription rates. in this review, we discuss possible mechanisms by which miRNAs control translation and mRNA degradation. An emerging theme is that miRNAs, and siRNAs to some extent, target mRNAs to the general eukaryotic machinery for mRNA degradation and translation control. |
| Document Type: Review |
| Language: English |
| Reprint Address: Parker, R (reprint author), Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA |
Addresses:
1. Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA
2. Univ Arizona, Howard Hughes Med Inst, Tucson, AZ 85721 USA
3. Watson Sch Biol Sci, Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA |
| Publisher: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2924 USA |
| Subject Category: Cell Biology; Developmental Biology; Genetics & Heredity |
| IDS Number: 018DV |
| ISSN: 0890-9369 |
| DOI: 10.1101/gad.1399806 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |