| Oncomirs - microRNAs with a role in cancer |
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| Author(s): Esquela-Kerscher A, Slack FJ |
| Source: NATURE REVIEWS CANCER Volume: 6 Issue: 4 Pages: 259-269 Published: APR 2006 |
| Times Cited: 631 References: 132 |
| Abstract: MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer. |
| Document Type: Review |
| Language: English |
| Reprint Address: Slack, FJ (reprint author), Yale Univ, Dept Mol Cellular & Dev Biol, 266 Whitney Ave, New Haven, CT 06520 USA |
Addresses:
1. Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Oncology |
| IDS Number: 025JP |
| ISSN: 1474-175X |
| DOI: 10.1038/nrc1840 |