| | |  | | | | Record from Web of Science® | | | | | | |
| Genetic regulators of large-scale transcriptional signatures in cancer |
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| Author(s): Adler AS, Lin MH, Horlings H, Nuyten DSA, van de Vijver MJ, Chang HY |
| Source: NATURE GENETICS Volume: 38 Issue: 4 Pages: 421-430 Published: APR 2006 |
| Times Cited: 75 References: 47 |
| Abstract: Gene expression signatures encompassing dozens to hundreds of genes have been associated with many important parameters of cancer, but mechanisms of their control are largely unknown. Here we present a method based on genetic linkage that can prospectively identify functional regulators driving large-scale transcriptional signatures in cancer. Using this method we show that the wound response signature, a poor-prognosis expression pattern of 512 genes in breast cancer, is induced by coordinate amplifications of MYC and CSN5 (also known as JAB1 or COPS5). This information enabled experimental recapitulation, functional assessment and mechanistic elucidation of the wound signature in breast epithelial cells. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chang, HY (reprint author), Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA |
Addresses:
1. Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA 94305 USA
2. Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA
3. Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Genetics & Heredity |
| IDS Number: 026LN |
| ISSN: 1061-4036 |
| DOI: 10.1038/ng1752 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |