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| TMPRSS2 : ETV4 gene fusions define a third molecular subtype of prostate cancer |
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| Author(s): Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgesson BE, Cao XH, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM |
| Source: CANCER RESEARCH Volume: 66 Issue: 7 Pages: 3396-3400 Published: APR 1 2006 |
| Times Cited: 123 References: 14 |
| Abstract: Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using a novel bioinformatic approach, we identified recurrent gene fusions between TMPRSS2 and the ETS family members ERG or ETV1 in the majority of prostate cancers. Here, we interrogated the expression of all ETS family members in prostate cancer profiling studies and identified marked overexpression of ETV4 in 2 of 98 cases. In one such case, we confirmed the overexpression of ETV4 using quantitative PCR, and by rapid amplification of cDNA ends, quantitative PCR, and fluorescence in situ hybridization, we show that the TMPRSS2 (21q22) and ETV4 (17q21) loci are fused in this case. This result defines it third molecular subtype of prostate cancer and supports the hypothesis that dysregulation of ETS family members through fusions with TMRPSS2 may be an initiating event in prostate cancer development. |
| Document Type: Article |
| Language: English |
| Reprint Address: Chinnaiyan, AM (reprint author), Univ Michigan, Sch Med, Dept Pathol, 1301 Catherine St,MSI 4237, Ann Arbor, MI 48109 USA |
Addresses:
1. Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
2. Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA
3. Univ Michigan, Sch Med, Program Bioinformat, Ann Arbor, MI 48109 USA
4. Univ Michigan, Sch Med, Urol Ctr, Ann Arbor, MI 48109 USA
5. Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
6. Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA
7. Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA |
| Subject Category: Oncology |
| IDS Number: 030TO |
| ISSN: 0008-5472 |
| DOI: 10.1158/0008-5472.CAN-06-0168 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |