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Review - Mass spectrometry and protein analysis
Author(s): Domon B, Aebersold R
Source: SCIENCE    Volume: 312    Issue: 5771    Pages: 212-217    Published: APR 14 2006  
Times Cited: 346     References: 36     
Abstract: Mass spectrometry is a central analytical technique for protein research and for the study of biomolecules in general. Driven by the need to identify, characterize, and quantify proteins at ever increasing sensitivity and in ever more complex samples, a wide range of new mass spectrometry based analytical platforms and experimental strategies have emerged. Here we review recent advances in mass spectrometry instrumentation in the context of current and emerging research strategies in protein science.
Document Type: Review
Language: English
Reprint Address: Domon, B (reprint author), ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
Addresses:
1. ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
2. Univ Zurich, Fac Sci, CH-8006 Zurich, Switzerland
3. Inst Mol Syst Biol, Seattle, WA 98103 USA
Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
Subject Category: Multidisciplinary Sciences
IDS Number: 032HK
ISSN: 0036-8075
DOI: 10.1126/science.1124619
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