| | |  | | | | Record from Web of Science® | | | | | | |
| The IL-23/IL-17 axis in inflammation |
|
|
| Author(s): Iwakura Y, Ishigame H |
| Source: JOURNAL OF CLINICAL INVESTIGATION Volume: 116 Issue: 5 Pages: 1218-1222 Published: MAY 2006 |
| Times Cited: 178 References: 29 |
| Abstract: IL-23 induces the differentiation of naive CD4(+) T cells into highly pathogenic helper T cells (Th17/ThIL-17) that produce IL-17, IL-17F, IL-6, and TNF-alpha, but not IFN-gamma and IL-4. Two studies in this issue of the JCI demonstrate that blocking IL-23 or its downstream factors IL-17 and IL-6, but not the IL-12/IFN-gamma pathways, can significantly suppress disease development in animal models of inflammatory bowel disease and MS (see the related articles beginning on pages 1310 and 1317). These studies suggest that the IL-23/IL-17 pathway may be a novel therapeutic target for the treatment of chronic inflammatory diseases. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Iwakura, Y (reprint author), Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan |
Addresses:
1. Univ Tokyo, Inst Med Sci, Ctr Med Expt, Minato Ku, Tokyo 1088639, Japan |
| Publisher: AMER SOC CLINICAL INVESTIGATION INC, 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA |
| Subject Category: Medicine, Research & Experimental |
| IDS Number: 038WH |
| ISSN: 0021-9738 |
| DOI: 10.1172/JCI28508 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |