| | |  | | | | Record from Web of Science® | | | | | | |
| Role of SGT1 in resistance protein accumulation in plant immunity |
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| Author(s): Azevedo C (Azevedo, Cristina), Betsuyaku S (Betsuyaku, Shigeyuki), Peart J (Peart, Jack), Takahashi A (Takahashi, Akira), Noel L (Noel, Laurent), Sadanandom A (Sadanandom, Ari), Casais C (Casais, Catarina), Parker J (Parker, Jane), Shirasu K (Shirasu, Ken) |
| Source: EMBO JOURNAL Volume: 25 Issue: 9 Pages: 2007-2016 Published: MAY 3 2006 |
| Times Cited: 55 References: 34 |
| Abstract: A highly conserved eukaryotic protein SGT1 binds specifically to the molecular chaperone, HSP90. In plants, SGT1 positively regulates disease resistance conferred by many Resistance (R) proteins and developmental responses to the phytohormone, auxin. We show that silencing of SGT1 in Nicotiana benthamiana causes a reduction in steady-state levels of the R protein, Rx. These data support a role of SGT1 in R protein accumulation, possibly at the level of complex assembly. In Arabidopsis, two SGT1 proteins, AtSGT1a and AtSGT1b, are functionally redundant early in development. AtSGT1a and AtSGT1b are induced in leaves upon infection and either protein can function in resistance once a certain level is attained, depending on the R protein tested. In unchallenged tissues, steady-state AtSGT1b levels are at least four times greater than AtSGT1a. While the respective tetratricopeptide repeat (TPR) domains of SGT1a and SGT1b control protein accumulation, they are dispensable for intrinsic functions of SGT1 in resistance and auxin responses. |
| Document Type: Article |
| Language: English |
| Reprint Address: Parker, J (reprint author), Max Planck Inst Zuchtungsforsch, Dept Plant Microbe Interact, Carl Von Linne Weg 10, D-50829 Cologne, Germany |
Addresses:
1. Max Planck Inst Zuchtungsforsch, Dept Plant Microbe Interact, D-50829 Cologne, Germany
2. John Innes Ctr, Sainsbury Lab, Norwich, Norfolk England
3. Univ Aix Marseille 2, Lab Biol Dev Plantes, UMR 6191, CEA,Cen Cadarache,CNRS, St Paul Les Durance, France |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 043HB |
| ISSN: 0261-4189 |
| DOI: 10.1038/sj.emboj.7601084 |
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