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| Nuclear factor-kappa B in cancer development and progression |
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| Author(s): Karin M |
| Source: NATURE Volume: 441 Issue: 7092 Pages: 431-436 Published: MAY 25 2006 |
| Times Cited: 555 References: 70 |
| Abstract: Nuclear factor-kappa B (NF-kappa B) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-kappa B signalling also has a critical role in cancer development and progression. NF-kappa B provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-kappa B might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches. |
| Document Type: Review |
| Language: English |
| Reprint Address: Karin, M (reprint author), Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, 9500 Gilman Dr, La Jolla, CA 92093 USA |
Addresses:
1. Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA |
| Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 045YP |
| ISSN: 0028-0836 |
| DOI: 10.1038/nature04870 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |