| | |  | | | | Record from Web of Science® | | | | | | |
| Simple sequence repeats as advantageous mutators in evolution |
|
|
| Author(s): Kashi Y (Kashi, Yechezkel), King DG (King, David G.) |
| Source: TRENDS IN GENETICS Volume: 22 Issue: 5 Pages: 253-259 Published: MAY 2006 |
| Times Cited: 77 References: 67 |
| Abstract: Simple sequence repeats (SSRs) often serve to modify genes with which they are associated. The influence of SSRs on gene regulation, transcription and protein function typically depends on the number of repeats, while mutations that add or subtract repeat units are both frequent and reversible. SSRs thus provide a prolific source of quantitative and qualitative variation. Over the past decade, researchers have found that this spontaneous variation has been tapped by natural and artificial selection to adjust almost every aspect of gene function. These studies support the hypothesis that SSRs, by virtue of their special mutational and functional qualities, have a major role in generating the genetic variation underlying adaptive evolution. |
| Document Type: Editorial Material |
| Language: English |
| Reprint Address: Kashi, Y (reprint author), Technion Israel Inst Technol, Dept Biotechnol & Food Engn, IL-32000 Haifa, Israel |
Addresses:
1. Technion Israel Inst Technol, Dept Biotechnol & Food Engn, IL-32000 Haifa, Israel
2. So Illinois Univ, Dept Anat, Carbondale, IL 62901 USA
3. So Illinois Univ, Dept Zool, Carbondale, IL 62901 USA |
| Publisher: ELSEVIER SCIENCE LONDON, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Genetics & Heredity |
| IDS Number: 047XT |
| ISSN: 0168-9525 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |