| | |  | | | | Record from Web of Science® | | | | | | |
| Wld(S) protection distinguishes axon degeneration following injury from naturally occurring developmental pruning |
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| Author(s): Hoopfer ED (Hoopfer, Eric D.), McLaughlin T (McLaughlin, Todd), Watts RJ (Watts, Ryan J.), Schuldiner O (Schuldiner, Oren), O'Leary DDM (O'Leary, Dennis D. M.), Luo LQ (Luo, Liqun) |
| Source: NEURON Volume: 50 Issue: 6 Pages: 883-895 Published: JUN 15 2006 |
| Times Cited: 51 References: 48 |
| Abstract: Axon pruning by degeneration remodels exuberant axonal connections and is widely required for the development of proper circuitry in the nervous system from insects to mammals. Developmental axon degeneration morphologically resembles injury-induced Wallerian degeneration, suggesting similar underlying mechanisms. As previously reported for mice, we show that Wld(s) protein substantially delays Wallerian degeneration in files. Surprisingly, Wld(s) has no effect on naturally occurring developmental axon degeneration in flies or mice, although it protects against injury-induced degeneration of the same axons at the same developmental age. By contrast, the ubiquitin-proteasome system is intrinsically required for both developmental and injury-induced axon degeneration. We also show that the glial cell surface receptor Draper is required for efficient clearance of axon fragments during developmental axon degeneration, similar to its function in injury-induced degeneration. Thus, mechanistically, naturally occurring developmental axon pruning by degeneration and injury-induced axon degeneration differ significantly in early steps, but may converge onto a common execution pathway. |
| Document Type: Article |
| Language: English |
| Reprint Address: O'Leary, DDM (reprint author), Salk Inst Biol Studies, Mol Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA |
Addresses:
1. Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
2. Stanford Univ, Dept Biol Sci, Howard Hughes Med Inst, Stanford, CA 94305 USA
3. Stanford Univ, Neurosci Program, Stanford, CA 94305 USA
4. Genentech Inc, San Francisco, CA 94080 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 057IM |
| ISSN: 0896-6273 |
| DOI: 10.1016/j.neuron.2006.05.013 |
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