| | |  | | | | Record from Web of Science® | | | | | | |
| Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond |
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| Author(s): Grossman AW (Grossman, Aaron W.), Aldridge GM (Aldridge, Georgina M.), Weiler IJ (Weiler, Ivan Jeanne), Greenough WT (Greenough, William T.) |
| Source: JOURNAL OF NEUROSCIENCE Volume: 26 Issue: 27 Pages: 7151-7155 Published: JUL 5 2006 |
| Times Cited: 57 References: 73 |
| Abstract: Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein). |
| Document Type: Review |
| Language: English |
| Reprint Address: Grossman, AW (reprint author), Univ Illinois, Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA |
Addresses:
1. Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
2. Univ Illinois, Grad Program Neurosci, Urbana, IL 61801 USA
3. Univ Illinois, Med Scholars Program, Urbana, IL 61801 USA
4. Univ Illinois, Dept Psychol, Urbana, IL 61801 USA
5. Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA
6. Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA |
| Publisher: SOC NEUROSCIENCE, 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA |
| Subject Category: Neurosciences |
| IDS Number: 060LW |
| ISSN: 0270-6474 |
| DOI: 10.1523/JNEUROSCI.1790-06.2006 |
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