| | |  | | | | Record from Web of Science® | | | | | | |
| Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis |
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| Author(s): Degenhardt K (Degenhardt, Kurt), Mathew R (Mathew, Robin), Beaudoin B (Beaudoin, Brian), Bray K (Bray, Kevin), Anderson D (Anderson, Diana), Chen GH (Chen, Guanghua), Mukherjee C (Mukherjee, Chandreyee), Shi YF (Shi, Yufang), Gelinas C (Gelinas, Celine), Fan YJ (Fan, Yongjun), Nelson DA (Nelson, Deirdre A.), Jin SK (Jin, Shengkan), White E (White, Eileen) |
| Source: CANCER CELL Volume: 10 Issue: 1 Pages: 51-64 Published: JUL 2006 |
| Times Cited: 199 References: 44 |
| Abstract: Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. In apoptosis-defective cells, inhibition of autophagy by AKT activation or by allelic disruption of beclin1 confers sensitivity to metabolic stress by inhibiting an autophagy-dependent survival pathway. While autophagy acts to buffer metabolic stress, the combined impairment of apoptosis and autophagy promotes necrotic cell death in vitro and in vivo. Thus, inhibiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth. Thus, autophagy may function in tumor suppression by mitigating metabolic stress and, in concert with apoptosis, by preventing death by necrosis. |
| Document Type: Article |
| Language: English |
| Reprint Address: White, E (reprint author), Ctr Adv Biotechnol & Med, 679 Hoes Lane, Piscataway, NJ 08854 USA |
Addresses:
1. Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
2. Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
3. Rutgers State Univ, Piscataway, NJ 08854 USA
4. Canc Inst New Jersey, New Brunswick, NJ 08903 USA
5. Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
6. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Mol Genet Microbiol & Immunol, Piscataway, NJ 08854 USA
7. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pharmacol, Piscataway, NJ 08854 USA
8. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Oncology |
| IDS Number: 066AW |
| ISSN: 1535-6108 |
| DOI: 10.1016/j.ccr.2006.06.001 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |