| | |  | | | | Record from Web of Science® | | | | | | |
| The PeptideAtlas project |
|
|
| Author(s): Desiere F (Desiere, Frank), Deutsch EW (Deutsch, Eric W.), King NL (King, Nichole L.), Nesvizhskii AI (Nesvizhskii, Alexey I.), Mallick P (Mallick, Parag), Eng J (Eng, Jimmy), Chen S (Chen, Sharon), Eddes J (Eddes, James), Loevenich SN (Loevenich, Sandra N.), Aebersold R (Aebersold, Ruedi) |
| Source: NUCLEIC ACIDS RESEARCH Volume: 34 Special Issue: Sp. Iss. SI Pages: D655-D658 Published: JAN 1 2006 |
| Times Cited: 77 References: 11 |
| Abstract: The completion of the sequencing of the human genome and the concurrent, rapid development of high-throughput proteomic methods have resulted in an increasing need for automated approaches to archive proteomic data in a repository that enables the exchange of data among researchers and also accurate integration with genomic data. PeptideAtlas (http://www.peptideatlas.org/) addresses these needs by identifying peptides by tandem mass spectrometry (MS/MS), statistically validating those identifications and then mapping identified sequences to the genomes of eukaryotic organisms. A meaningful comparison of data across different experiments generated by different groups using different types of instruments is enabled by the implementation of a uniform analytic process. This uniform statistical validation ensures a consistent and high-quality set of peptide and protein identifications. The raw data from many diverse proteomic experiments are made available in the associated PeptideAtlas repository in several formats. Here we present a summary of our process and details about the Human, Drosophila and Yeast PeptideAtlas builds. |
| Document Type: Article |
| Language: English |
| Reprint Address: Desiere, F (reprint author), Inst Syst Biol, Seattle, WA USA |
Addresses:
1. Inst Syst Biol, Seattle, WA USA
2. Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
3. Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90024 USA
4. Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA
5. Univ Zurich, Inst Zool, CH-8057 Zurich, Switzerland
6. ETH Honggerberg, Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland
7. Nestle Res Ctr, CH-1026 Lausanne, Switzerland |
| Publisher: OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: 067MR |
| ISSN: 0305-1048 |
| DOI: 10.1093/nar/gkj040 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |