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| The neuroligin and neurexin families: from structure to function at the synapse |
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| Author(s): Lise MF (Lise, M-F.), El-Husseini A (El-Husseini, A.) |
| Source: CELLULAR AND MOLECULAR LIFE SCIENCES Volume: 63 Issue: 16 Pages: 1833-1849 Published: AUG 2006 |
| Times Cited: 34 References: 167 |
| Abstract: Proper brain connectivity and neuronal transmission rely on the accurate assembly of neurotransmitter receptors, cell adhesion molecules and several other scaffolding and signaling proteins at synapses. Several new exciting findings point to an important role for the neuroligin family of adhesion molecules in synapse development and function. In this review, we summarize current knowledge of the structure of neuroligins and neurexins, their potential binding partners at the synapse. We also discuss their potential involvement in several aspects of synapse development, including induction, specificity and stabilization. The implication of neuroligins in cognitive disorders such as autism and mental retardation is also discussed. |
| Document Type: Review |
| Language: English |
| Reprint Address: El-Husseini, A (reprint author), Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 1Z3 Canada |
Addresses:
1. Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 1Z3 Canada
2. Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 1Z3 Canada |
| Publisher: BIRKHAUSER VERLAG AG, VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: 075ZZ |
| ISSN: 1420-682X |
| DOI: 10.1007/s00018-006-6061-3 |
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