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| DNA nanomachines and nanostructures involving quadruplexes |
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| Author(s): Alberti P (Alberti, Patrizia), Bourdoncle A (Bourdoncle, Anne), Sacca B (Sacca, Barbara), Lacroix L (Lacroix, Laurent), Mergny JL (Mergny, Jean-Louis) |
| Source: ORGANIC & BIOMOLECULAR CHEMISTRY Volume: 4 Issue: 18 Pages: 3383-3391 Published: 2006 |
| Times Cited: 31 References: 75 |
| Abstract: DNA is an attractive component for molecular recognition, because of its self-assembly properties. Its three-dimensional structure can differ markedly from the classical double helix. For example, DNA or RNA strands carrying guanine or cytosine stretches associate into four-stranded structures called G-quadruplexes or i-DNA, respectively. Since 2002, several groups have described nanomachines that take advantage of this structural polymorphism. We first introduce the unusual structures that are involved in these devices (i.e., i-DNA and G-quadruplexes) and then describe the opening and closing steps that allow cycling. A quadruplex - duplex molecular machine is then presented in detail, together with the rules that govern its formation, its opening/closing kinetics and the various technical and physico-chemical parameters that play a role in the efficiency of this device. Finally, we review the few examples of nanostructures that involve quadruplexes. |
| Document Type: Article |
| Language: English |
| Reprint Address: Mergny, JL (reprint author), Museum Natl Hist Nat, USM503, INSERM U565, CNRS UMR 5153,Lab Biophys, 43 Rue Cuvier, F-75231 Paris, France |
Addresses:
1. Museum Natl Hist Nat, USM503, INSERM U565, CNRS UMR 5153,Lab Biophys, F-75231 Paris, France |
| Publisher: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND |
| Subject Category: Chemistry, Organic |
| IDS Number: 079HP |
| ISSN: 1477-0520 |
| DOI: 10.1039/b605739j |
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