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| Decidual NK cells regulate key developmental processes at the human fetal-maternal interface |
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| Author(s): Hanna J (Hanna, Jacob), Goldman-Wohl D (Goldman-Wohl, Debra), Hamani Y (Hamani, Yaron), Avraham I (Avraham, Inbal), Greenfield C (Greenfield, Caryn), Natanson-Yaron S (Natanson-Yaron, Shira), Prus D (Prus, Diana), Cohen-Daniel L (Cohen-Daniel, Leonor), Arnon TI (Arnon, Tal I.), Manaster I (Manaster, Irit), Gazit R (Gazit, Roi), Yutkin V (Yutkin, Vladimir), Benharroch D (Benharroch, Daniel), Porgador A (Porgador, Angel), Keshet E (Keshet, Eli), Yagel S (Yagel, Simcha), Mandelboim O (Mandelboim, Ofer) |
| Source: NATURE MEDICINE Volume: 12 Issue: 9 Pages: 1065-1074 Published: SEP 2006 |
| Times Cited: 190 References: 49 |
| Abstract: Human CD56(bright) NK cells accumulate in the maternal decidua during pregnancy and are found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to explain the inability of NK cells to kill the semiallogeneic fetal cells. However, the actual functions of decidual NK (dNK) cells during pregnancy are mostly unknown. Here we show that dNK cells, but not peripheral blood - derived NK subsets, regulate trophoblast invasion both in vitro and in vivo by production of the interleukin-8 and interferon-inducible protein - 10 chemokines. Furthermore, dNK cells are potent secretors of an array of angiogenic factors and induce vascular growth in the decidua. Notably, such functions are regulated by specific interactions between dNK-activating and dNK-inhibitory receptors and their ligands, uniquely expressed at the fetal-maternal interface. The overall results support a 'peaceful' model for reproductive immunology, in which elements of innate immunity have been incorporated in a constructive manner to support reproductive tissue development. |
| Document Type: Article |
| Language: English |
| Reprint Address: Mandelboim, O (reprint author), Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel |
Addresses:
1. Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, IL-91120 Jerusalem, Israel
2. Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91120 Jerusalem, Israel
3. Hadassah Med Sch, Dept Mol Biol, IL-91120 Jerusalem, Israel
4. Hadassah Univ Hosp, Dept Pathol, IL-91120 Jerusalem, Israel
5. Hadassah Univ Hosp, Dept Urol, IL-91120 Jerusalem, Israel
6. Ben Gurion Univ Negev, Dept Microbiol & Immunol, IL-92865 Beer Sheva, Israel
7. Ben Gurion Univ Negev, Dept Pathol, IL-92865 Beer Sheva, Israel |
| Publisher: NATURE PUBLISHING GROUP, 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental |
| IDS Number: 082GE |
| ISSN: 1078-8956 |
| DOI: 10.1038/nm1452 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |