| | |  | | | | Record from Web of Science® | | | | | | |
| Double umbilical cord blood transplantation |
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| Author(s): Majhail NS (Majhail, Navneet S.), Brunstein CG (Brunstein, Claudio G.), Wagner JE (Wagner, John E.) |
| Source: CURRENT OPINION IN IMMUNOLOGY Volume: 18 Issue: 5 Pages: 571-575 Published: OCT 2006 |
| Times Cited: 42 References: 27 |
| Abstract: Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units. |
| Document Type: Review |
| Language: English |
| Reprint Address: Wagner, JE (reprint author), Univ Minnesota, Dept Pediat, Bone & Marrow Transplant Program, Minneapolis, MN 55455 USA |
Addresses:
1. Univ Minnesota, Dept Pediat, Bone & Marrow Transplant Program, Minneapolis, MN 55455 USA
2. Univ Minnesota, Dept Med, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA |
| Publisher: CURRENT BIOLOGY LTD, 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND |
| Subject Category: Immunology |
| IDS Number: 088MR |
| ISSN: 0952-7915 |
| DOI: 10.1016/j.coi.2006.07.015 |
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