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| Neuroligins determine synapse maturation and function |
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| Author(s): Varoqueaux F (Varoqueaux, Frederique), Aramuni G (Aramuni, Gayane), Rawson RL (Rawson, Randi L.), Mohrmann R (Mohrmann, Ralf), Missler M (Missler, Markus), Gottmann K (Gottmann, Kurt), Zhang WQ (Zhang, Weiqi), Sudhof TC (Suedhof, Thomas C.), Brose N (Brose, Nils) |
| Source: NEURON Volume: 51 Issue: 6 Pages: 741-754 Published: SEP 21 2006 |
| Times Cited: 109 References: 50 |
| Abstract: Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts. |
| Document Type: Article |
| Language: English |
| Reprint Address: Sudhof, TC (reprint author), Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany |
Addresses:
1. Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany
2. Max Planck Inst Expt Med, Ctr Mol Physiol Brain, D-37075 Gottingen, Germany
3. Univ Gottingen, Ctr Physiol & Pathophysiol, D-37073 Gottingen, Germany
4. Univ Gottingen, Ctr Mol Physiol Brain, D-37073 Gottingen, Germany
5. Ruhr Univ Bochum, Dept Cell Physiol ND4, D-44780 Bochum, Germany
6. Max Planck Inst Biophys Chem, Dept Membrane Biophys, D-37077 Gottingen, Germany
7. Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Ctr Basic Neurosci,Dept Mol Genet, Dallas, TX 75390 USA
8. Univ Magdeburg, Dept Genet & Mol Neurobiol, D-39106 Magdeburg, Germany
9. Univ Dusseldorf, Inst Neurophysiol & Sensory Physiol, D-40225 Dusseldorf, Germany |
| Publisher: CELL PRESS, 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA |
| Subject Category: Neurosciences |
| IDS Number: 091AM |
| ISSN: 0896-6273 |
| DOI: 10.1016/j.neuron.2006.09.003 |
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