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| Cancer regression in patients after transfer of genetically engineered lymphocytes |
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| Author(s): Morgan RA (Morgan, Richard A.), Dudley ME (Dudley, Mark E.), Wunderlich JR (Wunderlich, John R.), Hughes MS (Hughes, Marybeth S.), Yang JC (Yang, James C.), Sherry RM (Sherry, Richard M.), Royal RE (Royal, Richard E.), Topalian SL (Topalian, Suzanne L.), Kammula US (Kammula, Udai S.), Restifo NP (Restifo, Nicholas P.), Zheng ZL (Zheng, Zhili), Nahvi A (Nahvi, Azam), de Vries CR (de Vries, Christiaan R.), Rogers-Freezer LJ (Rogers-Freezer, Linda J.), Mavroukakis SA (Mavroukakis, Sharon A.), Rosenberg SA (Rosenberg, Steven A.) |
| Source: SCIENCE Volume: 314 Issue: 5796 Pages: 126-129 Published: OCT 6 2006 |
| Times Cited: 408 References: 19 |
| Abstract: Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor. Adoptive transfer of these transduced cells in 15 patients resulted in durable engraftment at levels exceeding 10% of peripheral blood lymphocytes for at least 2 months after the infusion. We observed high sustained levels of circulating, engineered cells at 1 year after infusion in two patients who both demonstrated objective regression of metastatic melanoma lesions. This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer. |
| Document Type: Article |
| Language: English |
| Reprint Address: Rosenberg, SA (reprint author), NCI, Surg Branch, Ctr Canc Res, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA |
Addresses:
1. NCI, Surg Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: 091LU |
| ISSN: 0036-8075 |
| DOI: 10.1126/science.1129003 |
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